- 产品编号：D0103
- 中文名称：2-脱氧-D-葡萄糖
- 英文名称：2-Deoxy-D-glucose
- 英文别名:2-Deoxy-D-arabinohexose, 2-Deoxyglucose
- CAS号:154-17-6
- 分子式:C6H12O5
- 分子量:164.16
- 纯度:≥98% (GC), crystalline
- EC号:205-823-0
- MDL号:MFCD00151328
性能描述
| 纯度 | ≥98% (GC) |
| form | crystalline |
| color | white to off-white |
| mp | 146-147 °C(lit.) |
Application
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.?
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.
