阿昔洛韦/无环鸟嘌呤/无环鸟苷/阿昔洛维/Acycloguanosine,≥99% (HPLC)
- 产品编号：A0169
- 中文名称：阿昔洛韦/无环鸟嘌呤/无环鸟苷/阿昔洛维/Acycloguanosine
- 英文名称：Acycloguanosine
- 英文别名:9-[(2-Hydroxyethoxy)methyl]guanine, Acyclovir
- CAS号:59277-89-3
- 分子式:C8H11N5O3
- 分子量:225.20
- 纯度:≥99% (HPLC)
- EC号:261-685-1
- MDL号:MFCD00057880
订货信息：
产品规格价格(RMB)
- A0169-1G
- A0169-10G
- A0169-100G
性能描述
| 试剂纯度 | ≥99% (HPLC) |
| form | powder |
| color | white |
| 溶解性 | H2O: soluble0.7 mg/mL |
| 1 M HCl: soluble50 mg/mL |
| DMSO: soluble7 mg/mL |
| abs. | ε1mM/256 nm 11.8 |
Biochem/physiol Actions
Antiviral agent. Phosphorylation by herpes simplex virus thymidine kinase (HSV-TK) leads to the formation of acycloguanosine triphosphate that competitively inhibits the viral DNA polymerase.
Antiviral agent. Phosphorylation by herpes simplex virus thymidine kinase (HSV-TK) leads to the formation of acycloguanosine triphosphate that competitively inhibits the viral DNA polymerase. Acycloguanosine can be used to induce apoptosis in cells transfected with HSV-TK. Inhibits replication of cytomegalovirus by a mechanism that is independent of its phosphorylation by viral or cellular thymidine kinase.
Application
Acycloguanosine has been used to study herpes simplex virus latency and reactivation, as well as HIV retrovirus reproduction. Acycloguanosine inhibits replication of cytomegalovirus by a mechanism that is independent of its phosphorylation by viral or cellular thymidine kinase.
