中文名称: 坦螺旋霉素
英文名称: Tanespimycin
别名: 坦螺旋霉素 (4E,6E,8S,9S,10E,12S,13R,14S,16R)-19-(allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate.
CAS.No: 75747-14-7 分子式: C31H43N3O8 分子量: 585.69
溶解性：
溶于DMSO(≥ 55 mg/mL 93.91 mM)
储存条件：
-20°C
包装：
10mg 25mg 100mg in glass bottle
产品描述：
一种有效的 HSP90 抑制剂。
Tanespimycin, also known as 17-AAG, is an orally bioavailable, small-molecule inhibitor of several receptor protein tyrosine kinases with potential antiangiogenic and antineoplastic activities. Telatinib binds to and inhibits the vascular endothelial growth factor receptors (VEGFRs) type 2 and 3, platelet-derived growth factor receptor beta (PDGFRb) and c-Kit, which may result in the inhibition of angiogenesis and cellular proliferation in tumors in which these receptors are upregulated. These telatinib-inhibited receptor protein tyrosine kinases are overexpressed or mutated in many tumor cell types and may play key roles in tumor angiogenesis and tumor cell proliferation.
