Ketoconazole/酮康唑/CAS 65277-42-1,≥98%
产品编号：K0105
中文名称：Ketoconazole/酮康唑/CAS 65277-42-1
英文名称：Ketoconazole
英文别名:(±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
CAS号:65277-42-1
分子式:C26H28Cl2N4O4
分子量:531.43
纯度:≥98%
EC号:265-667-4
MDL号:MFCD00058579

试剂纯度 ≥98%
保存温度 2-8°C
Biochem/physiol Actions
Antifungal agent，CYP3A4 inhibitor
Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model1, to study interleukin mediated antitumor effects, and drug interactions in vivo。
Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Other possible mechanisms of action are the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole inhibits the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone .