链脲佐菌素/链脲霉素/链氮霉素/ 链脲菌素/STZ/链唑霉素/Streptozocin,≥98% (HPLC)
- 产品编号：S0106
- 中文名称：链脲佐菌素/链脲霉素/链氮霉素/ 链脲菌素/STZ/链唑霉素/Streptozocin
- 英文名称：Streptozocin
- 英文别名:N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozotocin
- CAS号:18883-66-4
- 分子式:C8H15N3O7
- 分子量:265.22
- 纯度:≥98% (HPLC)
- EC号:242-646-8
- MDL号:MFCD00006607
Biochem/physiol Actions
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
Application
Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.
链脲佐菌素是一种氨基葡萄糖-亚硝基脲,是一种DNA烷基化试剂，能通过GLUT2葡萄糖转运蛋白（GLUT2 glucose trasport protein）独自进入细胞。对胰腺胰岛胰岛素诱发的β-细胞具毒性。链脲佐菌素对GLUT2阳性神经内分秘肿瘤细胞有毒性作用.
